Re sebelisa li-cookies ho ntlafatsa boiphihlelo ba hau. Ka ho tsoela pele ho sheba sebaka sena sa marang-rang, o lumellana le ts'ebeliso ea rona ea li-cookies. Lintlha tse ling.
Ka ho tobetsa "Lumella Tsohle", u lumela ho bolokoa ha li-cookies sesebelisoa sa hau ho ntlafatsa ts'ebetso ea sebaka sa marang-rang, ho sekaseka ts'ebeliso ea sebaka sa marang-rang, le ho ts'ehetsa tokisetso ea rona ea litaba tsa mahlale tse fumanehang mahala. Lintlha tse ling.
Phuputsong ea morao-rao e phatlalalitsoeng koranteng ea Pharmaceutics, bafuputsi ba fumane katleho ea antimicrobial ea motsoako oa litlama o bitsoang FRO khahlanong le acne pathogenesis.
Tlhahlobo ea lithibela-mafu le tlhahlobo ea in vitro e bontšitse hore FRO e na le litlamorao tse kholo tsa antibacterial le anti-inflammatory khahlano le Dermatobacillus Acnes (CA), baktheria e bakang makhopho. Liphetho tsena li bonts'a ts'ebeliso ea eona e bolokehileng le ea tlhaho kalafong ea litlolo ea li-acne, e ts'ehetsang ts'ebeliso ea mefuta e meng e se nang chefo le e theko e boima ho feta litlhare tsa morao-rao tsa makhopho.
Thuto: Ho sebetsa hantle ha FRO ho pathogenesis ea acne vulgaris. Setšoantšo sa mokitlane: Steve Jungs/Shutterstock.com
Acne vulgaris, eo ka tloaelo e tsejoang e le lihloba, ke boemo bo tloaelehileng ba letlalo bo bakoang ke li-follicle tsa moriri tse nang le sebum le lisele tsa letlalo tse shoeleng. Makhopho a ama karolo e fetang 80 lekholong ea bacha, ’me, le hoja a sa bolaee, a ka baka khatello ea kelello, ’me maemong a boima, a ba le ’mala o sa feleng oa letlalo le maqeba.
Li-acne li bakoa ke ho sebelisana ha liphatsa tsa lefutso le maemo a tikoloho, hangata a bakoang ke liphetoho tsa li-hormone tse tsamaeang le bohlankana nakong ea bokhachane. Ho se leka-lekane ha li-hormone ho eketsa tlhahiso ea sebum le ho eketsa insulin kgolo factor 1 (IGF-1) le dihydrotestosterone (DHT) mosebetsi.
Ho eketseha ha sebum secretion ho nkuoa e le mohato oa pele oa nts'etsopele ea makhopho, kaha li-follicle tsa moriri tse nang le sebum li na le palo e kholo ea likokoana-hloko tse kang SA. SA ke ntho ea tlhaho ea commensal ea letlalo; leha ho le joalo, ho ata ho eketsehileng ha phylotype IA1 ea eona ho baka ho ruruha le ho hlahisa mebala ea moriri ka li-papules tse bonahalang ka ntle.
Ho na le mefuta e fapaneng ea kalafo ea litlolo bakeng sa makhopho, joalo ka li-retinoids le li-topical microbial agents, tse sebelisoang hammoho le mapeele a lik'hemik'hale, kalafo ea laser/light, le li-hormone. Leha ho le joalo, liphekolo tsena li batla li tura ’me li amahanngoa le litla-morao tse mpe.
Liphuputso tse fetileng li hlahlobile li-extracts tsa litlama e le mefuta e meng ea tlhaho e sa sebetseng hantle bakeng sa liphekolo tsena. Joalo ka mokhoa o mong, li-extracts tsa Rhus vulgaris (RV) li ithutile. Leha ho le joalo, tšebeliso ea eona e lekanyelitsoe ke urushiol, karolo ea bohlokoa ea allergenic ea sefate sena.
FRO ke foromo ea litlama e nang le li-extracts tse lomositsoeng tsa RV (FRV) le Japanese mangosteen (OJ) ka karolelano ea 1:1. Ho sebetsa ha foromo ho lekoa ho sebelisoa liteko tsa in vitro le thepa ea antimicrobial.
Motsoako oa FRO o ile oa khetholloa ka lekhetlo la pele ka tšebeliso e phahameng ea metsi a chromatography (HPLC) ho arola, ho khetholla le ho lekanya likarolo tsa eona. Motsoako o ile oa hlahlojoa ka ho eketsehileng bakeng sa kakaretso ea phenolic content (TPC) ho khetholla metsoako e ka 'nang ea e-ba le thepa ea likokoana-hloko.
Teko ea pele ea in vitro antimicrobial ka ho hlahloba kutloisiso ea disc diffusion. Ntlha ea pele, CA (phylotype IA1) e ne e entsoe ka mokhoa o ts'oanang holim'a poleiti ea agar eo ho eona 10 mm bophara FRO-impregnated filter paper disk e behiloeng. Mosebetsi o thibelang likokoana-hloko o ile oa hlahlojoa ka ho lekanya boholo ba sebaka sa thibelo.
Katleho ea FRO mabapi le tlhahiso ea sebum e hlahisitsoeng ke CA le li-androgen surges tse amanang le DHT li ile tsa hlahlojoa ho sebelisoa Oil Red staining le Western blot analysis, ka ho latellana. Ka mor'a moo, FRO e ile ea lekoa bakeng sa bokhoni ba eona ba ho fokotsa liphello tsa mefuta e sa tšoaneng ea oksijene (ROS), e ikarabellang bakeng sa hyperpigmentation e amanang le acne le maqeba ka mor'a ho buuoa, ho sebelisa probe ea 2',7'-dichlorofluorescein diacetate (DCF-DA). sesosa.
Liphello tsa liteko tsa disk diffusion li bontšitse hore 20 μL ea FRO e atlehile ho thibela khōlo ea CA 'me e hlahisa sebaka se bonahalang sa thibelo ea 13 mm ka bongata ba 100 mg / mL. FRO e hatella haholo keketseho ea secretion ea sebum e bakoang ke SA, ka hona e fokotsa kapa e khutlisetsa morao ho hlaha ha makhopho.
FRO e fumanoe e ruile ka metsoako ea phenolic e kenyelletsang gallic acid, kaempferol, quercetin le fisetin. Kakaretso ea metsoako ea phenolic (TPC) e ka bang 118.2 mg gallic acid equivalents (GAE) ka gram FRO.
FRO e fokolitse haholo ho ruruha ha lisele tse bakoang ke SA-induced ROS le tokollo ea cytokine. Phokotso ea nako e telele ea tlhahiso ea ROS e ka fokotsa hyperpigmentation le maqeba.
Le hoja litlhare tsa dermatological bakeng sa maqoqomete li teng, hangata li bitsa chelete e ngata 'me li ka ba le litla-morao tse ngata tse sa batleheng.
Liphetho li bonts'a hore FRO e na le thepa ea antibacterial khahlano le CA (libaktheria tse bakang makhopho), ka hona li bonts'a hore FRO ke mokhoa o mong oa tlhaho, o se nang chefo le o theko e boima ho feta kalafo ea setso ea makhopho. FRO e boetse e fokotsa tlhahiso ea sebum le tlhahiso ea li-hormone in vitro, e bonts'a katleho ea eona ho alafong le ho thibela makhopho a makhopho.
Liteko tse fetileng tsa kliniki tsa FRO li bonts'itse hore batho ba sebelisang toner le lotion e tsoetseng pele ea FRO ba bile le lintlafatso tse kholo ho elasticity ea letlalo le maemo a mongobo ha ho bapisoa le sehlopha sa taolo kamora libeke tse ts'eletseng feela. Le hoja thuto ena e sa ka ea hlahloba li-acne tlas'a maemo a laoloang a vitro, liphetho tsa morao-rao li tšehetsa seo ba se fumaneng.
Ha li kopane, liphetho tsena li ts'ehetsa ts'ebeliso ea nako e tlang ea FRO kalafong ea litlolo, ho kenyelletsa kalafo ea makhopho le ho ntlafatsa bophelo bo botle ba letlalo.
Sengoliloeng sena se hlophisitsoe ka la 9 Phuptjane 2023 ho nkela setšoantšo sa mantlha sebaka ka se nepahetseng haholoanyane.
E ngotsoe ho: Litaba tsa Saense ea Bongaka | Litaba tsa Lipatlisiso tsa Bongaka | Litaba tsa Mafu | Litaba tsa meriana
Tags: makhopho, bacha, androgens, anti-inflammatory, lisele, chromatography, cytokines, dihydrotestosterone, katleho, belisoa, liphatsa tsa lefutso, lintlha tsa kgolo, moriri, li-hormone, hyperpigmentation, in vitro, ho ruruha, insulin, phototherapy, metsi chromatography, oksijene, ho ata , quercetin , retinoids, letlalo, lisele tsa letlalo, pigmentation ea letlalo, blot ea Bophirimela
Hugo Francisco de Souza ke sengoli sa mahlale se lulang Bangalore, Karnataka, India. Lithahasello tsa hae tsa thuto li mafapheng a biogeography, biology ea ho iphetola ha lintho le herpetology. Hona joale o ntse a sebetsa lengolong la hae la bongaka. ho tsoa Setsing sa Saense ea Tikoloho Setsing sa Saense sa India, moo a ithutang ka tšimoloho, kabo le mofuta oa linoha tsa mobung o mongobo. Hugo o ile a fuoa khau ea DST-INSPIRE Fellowship bakeng sa lipatlisiso tsa hae tsa bongaka le Khau ea Khauta ho tsoa Univesithing ea Pondicherry bakeng sa katleho ea hae ea thuto nakong ea lithuto tsa hae tsa Master. Patlisiso ea hae e phatlalalitsoe likoranteng tse hlahlobiloeng ke lithaka tse nang le tšusumetso e kholo ho kenyelletsa PLOS Neglected Tropical Diseases and Systems Biology. Ha a sa sebetse le ho ngola, Hugo o itlopa joala ka lithane tsa anime le metlae, o ngola le ho qapa 'mino ka katara ea bass, o qhekella lipina ho MTB, o bapala lipapali tsa video (o khetha lentsoe "papali"), kapa o bapala ka eng kapa eng. . mahlale.
Francisco de Souza, Hugo. (Phupu 9, 2023). Motsoako o ikhethang oa lihlahisoa tsa limela o fana ka melemo e matla ea anti-acne. Litaba - Bongaka. E tlisitsoe ka la 11 Loetse 2023, ho tsoa ho https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "Motsoako o ikhethang oa li-extracts tsa semela tse nang le thepa e matla ea anti-acne." Litaba - Bongaka. La 11 Loetse 2023 .
Francisco de Souza, Hugo. "Motsoako o ikhethang oa li-extracts tsa semela tse nang le thepa e matla ea anti-acne." Litaba - Bongaka. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (E fumaneha ka la 11 Loetse 2023).
Francisco de Souza, Hugo. 2023. Motsoako o ikhethang oa lihlahisoa tsa limela tse nang le thepa e matla ea anti-acne. News Medical, e fihletsoe ka la 11 Loetse 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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