Kankere ea matšoafo ke mofuta oa bobeli o atileng haholo oa mofetše lefatšeng. Ka 2020, batho ba fetang limilione tse 2.2 lefatšeng ka bophara ba tla fumanoa ba e-na le mofetše oa matšoafo khetlo la pele. Selemong sona seo, batho ba ka bang limilione tse 1,8 lefatšeng ka bophara ba ile ba bolaoa ke kankere ea matšoafo.
Le ha hona joale ho se na pheko ea mofetše oa matšoafo, bo-ramahlale ba ntse ba sebetsana le likhetho tsa kalafo. Ba bang ba bo-rasaense bana ba sebetsa Univesithing ea Theknoloji Sydney (UTS), moo phuputso e ncha e bontšitseng hore motsoako oa semela sa tlhaho o bitsoang berberine o ka thibela ho hōla ha lisele tsa kankere ea matšoafo ka laboratoring.
Berberine ke motsoako oa semela oa tlhaho o 'nileng oa sebelisoa meriana ea setso ea Machaena ka lilemo tse likete. E fumaneha limela tse fapaneng, ho kenyelletsa barberry, goldenseal, morara oa Oregon le turmeric ea sefate.

(Sehlahisoa sa rona keBerberine Extract, re amohelehile ka tieo ho botsa.)

Lilemo tsa lipatlisiso li bontšitse hore berberine e sebetsa hantle ho thusa batho ba nang le lefu la tsoekere la mofuta oa 2 ho laola maemo a tsoekere ea mali mme e ka thusa ho phekola lefu la metabolic.
Bafuputsi ba fumane hape hore berberine e ka sebelisoa ho phekola mefuta e fapaneng ea mofets'e, ho kenyelletsa le mofetše oa mahe, mala le matsoele.
Ho ea ka Dr. Kamal Dua, Senior Lecturer le Senior Research Fellow in Pharmacy at the Australian Research Center for Complementary and Integrative Medicine (ARCCIM), Univesithi ea Theknoloji Sydney (UTS) Sekolo sa Meriana le mongoli ea ka sehloohong oa thuto, Berberine e thibela lintlha tse peli tsa bohlokoa. lits'ebetso tsa nts'etsopele ea mofets'e - Ho ata le ho falla ha lisele.
"Ka mokhoa o ts'oanelang, sena se ka finyelloa ka ho thibela liphatsa tsa lefutso tsa bohlokoa tse kang P53, PTEN le KRT18 le liprotheine tse kang AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. le CAPG e amanang le ho ata le ho falla ha lisele tsa mofetše,” a hlalosa.
Phuputsong ea morao-rao, sehlopha sa lipatlisiso se kenyeletsang Dr. Dua, Dr. Keshav Raj Paudel, Moprofesa Philip M. Hansbrough le Dr. Bikash Manandhar oa UTS, hammoho le basebetsi ba Malaysian International Medical University le Al Qasim University Saudi Arabia, o ithutile kamoo berberine e ka sebelisoang ho phekola mofetše oa matšoafo.
"Tšebeliso ea bongaka ea berberine e lekanyelitsoe ka lebaka la ho fokola ha eona ho qhibiliha le bioavailability," ho hlalositse Dr. Dua bakeng sa MNT. "Sepheo se seholo sa thuto ena ke ho ntlafatsa likarolo tsa physicochemical tsa berberine ka ho fetola berberine hore e be metsi a kristale nanoparticles le ho hlahloba bokhoni ba eona ba anticancer in vitro liseleng tsa alveolar epithelial basal basal adenocarcinoma A549."
Sehlopha sa bafuputsi se thehile mokhoa o tsoetseng pele oa phano ea lithethefatsi o kenyellelitseng berberine likarolong tse nyane tse qhibilihang le tse senyehang. Li-nanoparticles tsena tsa kristale tsa metsi li sebelisitsoe ho alafa lisele tsa mofetše oa matšoafo a motho ka laboratoring.
Qetellong ea thuto, sehlopha se fumane hore berberine e thusitse ho thibela tlhahiso ea mefuta ea oksijene e sebetsang, lik'hemik'hale tsa ho ruruha tse hlahisoang ke lisele tse itseng ho arabela tlhaselo ea baktheria le liketsahalo tse ling tse sithabetsang tse ka senyang lisele.
Ho feta moo, berberine e thusa ho laola liphatsa tsa lefutso tse amanang le khatello ea oxidative le ho ruruha, 'me e thusa ho fokotsa botsofali ba lisele pele ho nako.
"Re bontšitse hore, ka ho sebelisa mokhoa oa nanotechnological, thepa ea motsoako e ka ntlafatsoa ho rarolla mathata a sa tšoaneng a amanang le ho qhibiliha, ho kenngoa ha lisele, le katleho ea phekolo," ho hlalositse Dr. Dua. Monyetla oa ho Thibela Mofetše Li-nanoparticles tsa rona tsa berberine liquid crystal nanoparticles li bontšitse ts'ebetso e ts'oanang ka makhetlo a mahlano ha li bapisoa le lingoliloeng tse hatisitsoeng, li bonts'a ka ho hlaka melemo ea li-nanodrugs.
Ho tsoela pele ho hlahloba liphetho tsena, Dr. Dua o re o rerile ho sebelisa sethala se secha sa lipatlisiso ho etsa lithuto tse tebileng a sebelisa mefuta ea pele ea liphoofolo tsa kankere ea matšoafo.
"Lithuto tse ling tsa pharmacokinetic le anticancer tsa berberine nanodrugs mefuteng ea liphoofolo ka vivo li ka senola melemo ea tsona e ka bang teng kalafong ea mofetše oa matšoafo le ho li fetola mefuta ea litekanyetso tsa kalafo," o hlalositse.
"Ha re se re netefalitse matla a khahlanong le kankere ea berberine nanodrugs mefuteng ea liphoofolo tsa preclinical, mohato o latelang e tla ba ho fallela litekong tsa meriana, tseo re seng re ntse re buisana le likhamphani tse 'maloa tsa Sydney," ho boletse Dr. Dua.
Ho phaella moo, Dr. Dua o boletse hore bokhoni ba berberine ho thibela ho khutla ha kankere ea matšoafo bo hloka ho netefatsoa: "Le hoja re e-s'o batlisise sena, re rerile ho ithuta ka eona lithutong tse tlang, hape re lumela hore berberine nanoforms e tla bontša. mosebetsi o tshepisang. “.
Dr. Osita Onuga, ngaka e buoang ea sefuba le motlatsi oa moprofesa oa opereishene ea sefuba Setsing sa St. John Cancer se Providence St. John Medical Center e Santa Monica, California, o ile a bolella MNT hore ha bafuputsi ba fumana menyetla e mecha ea ho phekola le ho thibela kankere, ho na le kamehla. tšepo:
"Berberine ke karolo ea meriana ea Bochabela, kahoo ha re e sebelise ka tloaelo meriana ea Bophirimela. Ke nahana hore hoa thahasellisa hobane re sheba seo re tsebang hore se na le melemo e itseng bakeng sa lintho tsa meriana ea Bochabela, 'me re se kenye lipatlisisong ho thusa ho fetolela meriana ea Bophirimela. “.
"E lula e ts'episa, empa e ka laboratoring, 'me lintho tse ngata tseo re li fumanang ka lab ha li etse hore bakuli ba phekoloe," Onuga a tsoela pele. "Ke nahana hore ntho e latelang e lokelang ho etsoa ke ho etsa liteko tsa bongaka ho bakuli le ho fumana litekanyetso."
Batho ba bang ba na le matšoao a poteletseng a kankere ea matšoafo nakong ea pele ea lefu lena. Tsoela pele ho bala ho ithuta haholoanyane, ho kenyelletsa le nako ea ho bona ngaka.
Kankere ea matšoafo e hlaha ka litekanyetso tse fapaneng ho basali le banna, empa matšoao le mabaka a kotsi aa tšoana. Mona re hlalosa liphatsa tsa lefutso le lihormone tse ka bang teng ...
Re baetsi ba phofo ba hloahloa ba limela, re amohelehile ho u romella lipotso leha e le life mabapi le sehlahisoa sa rona mme re na le basebetsi-'moho le rona ba ikarabellang ho rarolla mathata a hau mabapi le thekiso ea pele le ka mor'a thekiso. Ikopanye le Rona Ka Nako Efe kapa Efe !!!