'Mele oa hau o e sebelisa ho hlahisa serotonin, lenģosa la lik'hemik'hale le romelang melaetsa pakeng tsa lisele tsa methapo.
Serotonin e tlase e amahanngoa le khatello ea maikutlo, matšoenyeho, tšitiso ea boroko, boima ba 'mele le mathata a mang a bophelo bo botle (1, 2).
Ho lahleheloa ke boima ba 'mele ho eketsa tlhahiso ea lihomone tse bakang tlala.Boikutlo bona bo sa feleng ba tlala bo ka etsa hore tahlehelo ea boima ba 'mele e se ke ea tšoarella nako e telele (3, 4, 5).
5-HTP e ka hanyetsa lihomone tsena tse bakang tlala tse hatellang takatso ea lijo le ho u thusa ho theola boima ba 'mele (6).
Phuputsong e 'ngoe, bakuli ba 20 ba lefu la tsoekere ba ile ba abeloa ho amohela 5-HTP kapa placebo ka libeke tse peli.Liphetho li bonts'itse hore ba amohetseng 5-HTP ba ne ba ja likhalori tse fokolang tsa 435 ka letsatsi ha ba bapisoa le sehlopha sa placebo (7).
Ho feta moo, 5-HTP haholo-holo e hatella ho kenngoa ha lik'habohaedreite, tse amanang le taolo e ntle ea glycemic (7).
Liphuputso tse ling tse ngata li boetse li bontšitse hore 5-HTP e eketsa satiety mme e khothalletsa ho theola boima ba 'mele ho batho ba batenya haholo kapa ba batenya (8, 9, 10, 11).
Ho phaella moo, lithuto tsa liphoofolo li bontšitse hore 5-HTP e ka fokotsa ho ja lijo tse feteletseng ka lebaka la khatello ea kelello kapa khatello ea maikutlo (12, 13).
5-HTP e ka 'na ea sebetsa ho eketsa ho khora, ho ka u thusang ho ja hanyenyane le ho theola boima ba' mele.
Le ha sesosa sa ho tepella maikutlong se sa tsejoe haholo, bafuputsi ba bang ba lumela hore ho se leka-lekane ha serotonin ho ka ama maikutlo a hau, ho lebisa ho tepella maikutlong (14, 15).
Ha e le hantle, liphuputso tse 'maloa tse nyenyane li bontšitse hore 5-HTP e ka fokotsa matšoao a ho tepella maikutlong.Leha ho le joalo, ba babeli ba bona ha baa ka ba sebelisa placebo ho bapisa, e leng se ileng sa fokotsa bonnete ba liphetho tsa bona (16, 17, 18, 19).
Leha ho le joalo, liphuputso tse ngata li bonts'itse hore 5-HTP e na le phello e matla ea antidepressant ha e sebelisoa hammoho le lintho tse ling kapa li-antidepressants ho feta ha e sebelisoa e le mong (17, 21, 22, 23).
Ntle le moo, litlhahlobo tse ngata li fihletse qeto ea hore lipatlisiso tsa boleng bo holimo lia hlokahala pele 5-HTP e ka khothaletsoa bakeng sa kalafo ea khatello ea maikutlo (24, 25).
Li-supplement tsa 5-HTP li eketsa maemo a serotonin 'meleng, e ka imollang matšoao a ho tepella maikutlong, haholo-holo ha a kopantsoe le li-antidepressants tse ling kapa meriana.Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng.
Tlatsetso ea 5-HTP e ka ntlafatsa matšoao a fibromyalgia, lefu le khetholloang ke bohloko ba mesifa le masapo le bofokoli bo akaretsang.
Hajoale ha ho na sesosa se tsebahalang sa fibromyalgia, empa maemo a tlase a serotonin a hokahane le boemo bona (26Trusted Source).
Sena se etsa hore bafuputsi ba lumele hore ho eketsa maemo a serotonin ka li-supplement tsa 5-HTP ho ka thusa batho ba nang le fibromyalgia (27).
Ebile, bopaki ba pele bo fana ka maikutlo a hore 5-HTP e ka ntlafatsa matšoao a fibromyalgia, ho kenyelletsa bohloko ba mesifa, mathata a boroko, matšoenyeho le mokhathala (28, 29, 30).
Leha ho le joalo, ha hoa etsoa lipatlisiso tse lekaneng ho fihlela liqeto leha e le life tse tiileng mabapi le katleho ea 5-HTP ho ntlafatsa matšoao a fibromyalgia.
5-HTP e eketsa maemo a serotonin 'meleng, e ka imollang a mang a matšoao a fibromyalgia.Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng.
Ho boleloa hore 5-HTP e thusa ho phekola migraine, mofuta oa hlooho e atisang ho tsamaisana le ho nyekeloa ke pelo kapa tšitiso ea pono.
Leha ho ntse ho phehisana khang ka lebaka la bona, bafuputsi ba bang ba lumela hore ba bakoa ke maemo a tlase a serotonin (31, 32).
Phuputso ea batho ba 124 e bapisoa le bokhoni ba 5-HTP le methylergometrine, meriana e tloaelehileng ea migraine, ho thibela hlooho ea hlooho ea migraine (33).
Phuputso e fumane hore ho nka 5-HTP letsatsi le leng le le leng ka likhoeli tse tšeletseng ho thibela kapa ho fokotsa haholo palo ea litlhaselo tsa migraine ho 71% ea barupeluoa (33).
Phuputsong e 'ngoe ea liithuti tsa 48, 5-HTP e fokolitse maqhubu a hlooho ka 70% ha e bapisoa le 11% sehlopheng sa placebo (34).
Ka mokhoa o ts'oanang, liphuputso tse ling tse ngata li bontšitse hore 5-HTP e ka ba phekolo e sebetsang bakeng sa migraines (30, 35, 36).
Melatonin e phetha karolo ea bohlokoa ho laola boroko.Maemo a eona a qala ho phahama bosiu ho khothaletsa boroko le ho oela hoseng ho u thusa ho tsoha.
Ka hona, tlatsetso ea 5-HTP e ka khothaletsa boroko ka ho eketsa tlhahiso ea melatonin 'meleng.
Phuputso ea batho e fumane hore motsoako oa 5-HTP le gamma-aminobutyric acid (GABA) o fokolitse haholo nako ea ho robala, ho eketsa nako ea ho robala, le ho ntlafatsa boleng ba boroko (37).
GABA ke lenģosa la lik'hemik'hale le khothalletsang phomolo.Ho e kopanya le 5-HTP ho ka ba le phello ea synergistic (37).
Ha e le hantle, lithuto tse 'maloa tsa liphoofolo le likokoanyana li bontšitse hore 5-HTP e ntlafatsa boleng ba boroko' me e molemo le ho feta ha e kopantsoe le GABA (38, 39).
Le hoja liphetho tsena li tšepisa, khaello ea lithuto tsa batho e etsa hore ho be thata ho khothaletsa 5-HTP bakeng sa ho ntlafatsa boleng ba boroko, haholo-holo ha e sebelisoa e le mong.
Batho ba bang ba ka ba le ho nyekeloa ke pelo, letšollo, ho hlatsa le mahlaba ka mpeng ha ba ntse ba nka li-supplement tsa 5-HTP.Litla-morao tsena li itšetlehile ka litekanyetso, ho bolelang hore li mpefala le ho feta ha lethal dose le ntse le eketseha (33).
Ho fokotsa litla-morao tsena, qala ka tekanyo ea 50-100 mg habeli ka letsatsi 'me u eketsehe ho tekanyo e nepahetseng ka libeke tse peli (40).
Meriana e meng e eketsa tlhahiso ea serotonin.Ho kopanya lithethefatsi tsena le 5-HTP ho ka baka maemo a kotsi a serotonin 'meleng.Sena se bitsoa serotonin syndrome, boemo bo ka behang bophelo kotsing (41).
Meriana e ka eketsang maemo a serotonin 'meleng e kenyelletsa li-antidepressants tse itseng, litlhare tsa ho khohlela, kapa litlhare tse tsoang ho ngaka.
Hobane 5-HTP e ka boela ea khothalletsa boroko, ho e nka ka li-sedative tse kang Klonopin, Ativan, kapa Ambien ho ka baka boroko bo feteletseng.
Ka lebaka la litšebelisano tse mpe tse ka bang teng le meriana e meng, botsa ngaka kapa setsebi sa meriana pele u nka li-supplement tsa 5-HTP.
Ha u reka li-supplement, sheba litiiso tsa NSF kapa USP tse bontšang boleng bo phahameng.Tsena ke likhamphani tsa batho ba boraro tse tiisang hore li-supplement li na le se boletsoeng leiboleng 'me ha li na litšila.
Batho ba bang ba ka ba le litla-morao ha ba nka li-supplement tsa 5-HTP.Buisana le ngaka ea hau pele u nka 5-HTP ho etsa bonnete ba hore e bolokehile bakeng sa hau.
Li-supplement tsena li fapane le li-supplement tsa L-tryptophan, tse ka eketsang maemo a serotonin (42).
L-tryptophan ke amino acid ea bohlokoa e fumanehang lijong tse nang le protheine tse ngata joalo ka lebese, likhoho, nama, lierekisi tsa litsuonyana le soya.
Ka lehlakoreng le leng, 5-HTP ha e fumanehe lijong mme e ka eketsoa feela lijong tsa hau ka li-supplement tsa lijo (43).
'Mele oa hau o fetola 5-HTP ho serotonin, ntho e laolang takatso ea lijo, maikutlo a bohloko le boroko.
Maemo a phahameng a serotonin a ka ba le melemo e mengata, joalo ka ho theola boima ba 'mele, ho imolla matšoao a khatello ea maikutlo le fibromyalgia, ho fokotsa khafetsa ho hlaseloa ke migraine, le ho robala hantle.
Litla-morao tse nyane li 'nile tsa amahanngoa le 5-HTP, empa tsena li ka fokotsoa ka ho qala ka litekanyetso tse nyenyane le ho eketsa tekanyo ea butle-butle.
Kaha 5-HTP e ka sebelisana hampe le meriana e itseng, botsa ngaka ea hau ho netefatsa hore e bolokehile bakeng sa hau.
Litsebi tsa rona li lula li beha leihlo sebaka sa bophelo bo botle le bophelo bo botle le ho nchafatsa lingoliloeng tsa rona ha tlhaiso-leseling e ncha e ntse e fumaneha.
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