Har'a lipampiri tsa morao-rao tse mabapi le antioxidant ena e matla ke tlhahlobo e phatlalalitsoeng ho Phytotherapy Research ka Hlakubele 2019, e ileng ea hlahloba lintho tse 9 mabapi le litlamorao tsa quercetin ho metabolic syndrome Teko e laoloang ka mokhoa o sa reroang.

Metabolic syndrome e bua ka letoto la mathata a bophelo bo botle a eketsang kotsi ea lefu la tsoekere la mofuta oa 2, lefu la pelo le stroke, ho kenyelletsa khatello e phahameng ea mali, tsoekere e phahameng ea mali, maemo a phahameng a triglyceride le ho bokellana ha mafura thekeng.

Leha liphuputso tse felletseng li fumane hore quercetin ha e na phello ho tsoekere ea mali e potlakileng, ho hanyetsa insulin kapa maemo a hemoglobin A1c, tlhahlobo e 'ngoe ea sehlopha se senyenyane e bontšitse hore quercetin e tlatsellelitsoe lithutong tse nkileng bonyane 500 mg ka letsatsi bonyane libeke tse robeli. Ho fokotseha ho hoholo ha tsoekere ea mali ho itima lijo.

Quercetin e thusa ho laola liphatsa tsa lefutso

Ho ea ka phuputso e phatlalalitsoeng ka 2016, quercetin e ka boela ea kenya tšebetsong mocha oa mitochondrial oa apoptosis (lefu la lisele tse senyehileng) ka ho sebelisana le DNA, kahoo e baka ho fokotseha ha hlahala.

Liphuputso li fumane hore quercetin e ka susumetsa cytotoxicity ea lisele tsa leukemia, 'me phello e amana le lethal dose. Litlamorao tse fokolang tsa cytotoxic le tsona li fumanoe liseleng tsa mofetše oa matsoele. Ka kakaretso, quercetin e ka eketsa nako ea bophelo ea litoeba tsa mofets'e ka makhetlo a 5 ha e bapisoa le sehlopha sa taolo se sa sebetsoeng.

Bangoli ba re litlamorao tsena li bakoa ke tšebelisano e tobileng lipakeng tsa quercetin le DNA le ts'ebetso ea eona ea tsela ea mitochondrial ea apoptosis, mme ba fana ka maikutlo a hore ts'ebeliso e ka bang teng ea quercetin joalo ka setlhare sa adjuvant bakeng sa kalafo ea mofets'e e lokeloa ke tlhahlobo e eketsehileng.

Phuputso ea morao-rao e hatisitsoeng koranteng ea Molecules e boetse e totobatsa liphello tsa epigenetic tsa quercetin le bokhoni ba eona ba ho:

Ho sebelisana le likanale tsa lipontšo tsa lisele
Laola tlhahiso ea liphatsa tsa lefutso
Ama tšebetso ea lintlha tsa mongolo
E laola microribonucleic acid (microRNA)

Microribonucleic acid e kile ea nkoa e le "DNA" e se nang thuso. Liphuputso li fumane hore DNA “ea litšila” ha e na thuso ho hang. Ha e le hantle ke molek'hule e nyenyane ea ribonucleic acid, e phethang karolo ea bohlokoa ho laola liphatsa tsa lefutso tse etsang liprotheine tsa motho.

Microribonucleic acid e ka sebelisoa e le "switch" ea liphatsa tsa lefutso tsena. Ho latela tlhahiso ea microribonucleic acid, phatsa ea lefutso e ka kenyelletsa leha e le efe ea lihlahisoa tse fetang 200 tsa protheine. Bokhoni ba Quercetin ba ho fetola li-microRNA le bona bo ka hlalosa litlamorao tsa eona tsa cytotoxic le hore na hobaneng ho bonahala ho eketsa pholoho ea mofets'e (bonyane bakeng sa litoeba).

Quercetin ke motsoako o matla oa antiviral

Joalokaha ho boletsoe ka holimo, lipatlisiso tse entsoeng ho pota quercetin li shebane le bokhoni ba eona ba antiviral, e leng haholo-holo ka lebaka la mekhoa e meraro ea ts'ebetso:

Thibela bokhoni ba livaerase ho tšoaetsa lisele
Thibela ho ikatisa ha lisele tse tšoaelitsoeng
Fokotsa khanyetso ea lisele tse nang le tšoaetso ho kalafo ea lithethefatsi tse thibelang likokoana-hloko

Ka mohlala, phuputso e tšehetsoeng ke Lefapha la Tšireletso la United States e hatisitsoeng ka 2007 e fumane hore ka mor'a ho ba le khatello ea kelello e feteletseng ea 'mele, quercetin e ka fokotsa kotsi ea ho tšoaetsoa kokoana-hloko le ho ntlafatsa ts'ebetso ea kelello ea hau, ho seng joalo e ka senya ts'ebetso ea hau ea' mele ea ho itšireletsa mafung , Ho etsa hore u hlaseloe haholoanyane. ho mafu.

Phuputsong ena, bapalami ba libaesekele ba fumane 1000 mg ea quercetin ka letsatsi, e kopantsoe le vithamine C (e eketsang maemo a quercetin ea plasma) le niacin (e khothalletsang ho monya) libeke tse hlano tse latellanang. Liphello li fumane hore ha li bapisoa le tse sa phekoloeng Ho mopalami ofe kapa ofe oa libaesekele ea ileng a phekoloa, ba neng ba nka quercetin ba ne ba e-na le monyetla o fokolang haholo oa ho tšoaroa ke lefu la kokoana-hloko ka mor'a ho palama baesekele lihora tse tharo ka letsatsi ka matsatsi a mararo a latellanang. 45% ea batho ba sehlopheng sa placebo ba ne ba kula, athe ke 5% feela ea batho ba sehlopheng sa kalafo ba neng ba kula.

US Defense Advanced Research Projects Agency (DARPA) e tšehelitse ka lichelete thuto e 'ngoe, e ileng ea hatisoa ka 2008, 'me ea ithuta ka tšebeliso ea kokoana-hloko ea feberu ea H1N1 ho qholotsa liphoofolo tse phekoloang ka quercetin. Sephetho se ntse se tšoana, lefu le lefu la sehlopha sa kalafo li ne li le tlase haholo ho feta tsa sehlopha sa placebo. Lithuto tse ling le tsona li netefalitse katleho ea quercetin khahlano le livaerase tse fapaneng, ho kenyelletsa:

Phuputso e entsoeng ka 1985 e fumane hore quercetin e ka thibela tšoaetso le ho ikatisa ha kokoana-hloko ea herpes simplex mofuta oa 1, mofuta oa poliovirus oa mofuta oa 1, kokoana-hloko ea parainfluenza ea mofuta oa 3, le kokoana-hloko ea ho hema ea syncytial.

Phuputso ea liphoofolo ka 2010 e fumane hore quercetin e ka thibela livaerase tsa ntaramane A le B. Ho boetse ho na le litšibollo tse peli tse kholo. Ntlha ea pele, likokoana-hloko tsena ha li khone ho hanyetsa quercetin; ea bobeli, haeba li sebelisoa hammoho le lithethefatsi tse thibelang likokoana-hloko (amantadine kapa oseltamivir), liphello tsa tsona li ntlafatsoa haholo-'me tsoelo-pele ea ho hanyetsa e thibeloa.

Boithuto ba liphoofolo ka 2004 bo amohetse mofuta oa vaerase ea H3N2, ho batlisisa phello ea quercetin ho ntaramane. Mongoli o boletse:

"Nakong ea tšoaetso ea kokoana-hloko ea ntaramane, khatello ea oxidative e etsahala. Hobane quercetin e ka tsosolosa mahloriso a li-antioxidants tse ngata, batho ba bang ba nahana hore e ka 'na ea e-ba moriana o sebetsang o ka sireletsang matšoafo ho lokolloa nakong ea tšoaetso ea kokoana-hloko ea ntaramane. Liphello tse kotsi tsa li-radicals tsa mahala tsa oksijene. "

Phuputso e 'ngoe ea 2016 e fumane hore quercetin e ka laola polelo ea protheine mme e na le ts'ireletso ho kokoana-hloko ea ntaramane ea H1N1. Haholo-holo, taolo ea protheine e tšosang ea mocheso, fibronectin 1 le protheine ea inhibitory e thusa ho fokotsa ho ikatisa ha vaerase.

Phuputso ea boraro e phatlalalitsoeng ka 2016 e fumane hore quercetin e ka thibela mefuta e fapaneng ea mafu a ntaramane, ho kenyelletsa H1N1, H3N2, le H5N1. Sengoli sa tlaleho ea lipatlisiso se lumela hore, "Phuputso ena e bontša hore quercetin e bonts'a ts'ebetso ea thibelo qalong ea ts'oaetso ea ntaramane, e fanang ka moralo oa kalafo o ka khonehang oa nakong e tlang ka nts'etsopele ea meriana ea tlhaho e sebetsang, e bolokehileng le e theko e tlaase ho alafa le ho thibela [Influenza. A virus] tšoaetso."

Ka 2014, bafuputsi ba ile ba bontša hore quercetin "e bonahala e tšepisa ho phekola sefuba se tloaelehileng se bakoang ke li-rhinoviruses" 'me a phaella ka ho re, "Lipatlisiso li tiisitse hore quercetin e ka fokotsa ho kenngoa ka hare le ho pheta-pheta ha likokoana-hloko ka har'a vitro. 'Mele o ka fokotsa bongata ba kokoana-hloko, nyumonia le khatello e phahameng ea moea."

Quercetin e ka boela ea fokotsa tšenyo ea oxidative, kahoo e fokotsa kotsi ea tšoaetso ea bobeli ea baktheria, e leng sesosa se ka sehloohong sa lefu le amanang le ntaramane. Habohlokoa, quercetin e eketsa biosynthesis ea mitochondrial ka har'a mesifa ea masapo, e bonts'ang hore karolo ea phello ea eona ea antiviral e bakoa ke lets'oao le ntlafalitsoeng la mitochondrial antiviral.

Phuputso ea liphoofolo ka 2016 e fumane hore quercetin e ka thibela kokoana-hloko ea dengue le tšoaetso ea kokoana-hloko ea lefu la sebete ho litoeba. Liphuputso tse ling le tsona li netefalitse hore quercetin e na le matla a ho thibela tšoaetso ea hepatitis B le C.

Haufinyane tjena, phuputso e phatlalalitsoeng koranteng ea Microbial Pathogenesis ka Hlakubele 2020 e fumane hore quercetin e ka fana ka tšireletso e felletseng khahlano le ts'oaetso ea Streptococcus pneumoniae in vitro le vivo. Chefo (PLY) e hlahisoang ke pneumococcus ho thibela ho qhoma ha tšoaetso ea Streptococcus pneumoniae. Tlalehong ea "Microbial Pathogenesis", mongoli o bontšitse:

"Liphetho li bontša hore quercetin e fokotsa haholo ts'ebetso ea hemolytic le cytotoxicity e bakoang ke PLY ka ho thibela ho thehoa ha oligomers.
Ho phaella moo, phekolo ea quercetin e ka boela ea fokotsa tšenyo ea lisele tsa PLY, ea eketsa lebelo la ho pholoha ha litoeba tse nang le litekanyetso tse bolaeang tsa Streptococcus pneumoniae, ho fokotsa tšenyo ea matšoafo, le ho thibela li-cytokines (IL-1β le TNF) ho bronchoalveolar lavage fluid. -α) ho lokolloa.
Ha re nahana ka bohlokoa ba liketsahalo tsena ho pathogenesis ea Streptococcus pneumoniae e hanyetsang, liphetho tsa rona li bontša hore quercetin e ka fetoha moemeli e mocha oa lithethefatsi bakeng sa phekolo ea mafu a kliniki a pneumococcal. "
Quercetin e loantša ho ruruha le ho matlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung

Ntle le ts'ebetso ea antiviral, quercetin e ka boela ea matlafatsa sesole sa 'mele le ho loantša ho ruruha. Phuputso ea 2016 e phatlalalitsoeng koranteng ea Nutrients e bontšitse hore mekhoa ea ts'ebetso e kenyelletsa (empa ha e felle feela) ho thibela:

• Tumor necrosis factor alpha (TNF-α) e bakoang ke lipopolysaccharide (LPS) ka macrophages. TNF-α ke cytokine e amehang ho ruruha ha tsamaiso. E hlahisoa ke macrophages e kentsoeng. Macrophages ke lisele tsa 'mele tsa ho itšireletsa mafung tse ka metsang lintho tse tsoang linaheng tse ling, likokoana-hloko le likarolo tse ling tse kotsi kapa tse senyehileng.
• Lipopolysaccharide-induced TNF-α le interleukin (Il) -1α mRNA maemo a lisele tsa glial, tse ka lebisang "ho fokotseha ha neuronal cell apoptosis"
• Thibela tlhahiso ea li-enzyme tse bakang ho ruruha
• Thibela khalsiamo hore e se ke ea phalla ka har'a lisele, kahoo e thibela:
◦ Ho lokolloa ha li-cytokine tsa pro-inflammatory
◦ Lisele tsa mala a mala li lokolla histamine le serotonin 

Ho ea ka sehlooho sena, quercetin e ka boela ea tsitsisa lisele tsa mast, e na le ts'ebetso ea cytoprotective ka pampitšana ea gastrointestinal, 'me "e na le phello e tobileng ea taolo holim'a litšobotsi tsa motheo tsa ts'ebetso ea lisele tsa' mele oa ho itšireletsa mafung", e le hore e ka "theola-ho laola kapa ho thibela mefuta e sa tšoaneng. likanale le mesebetsi ea ho ruruha," Thibela palo e kholo ea sepheo sa limolek'hule sebakeng sa mahloriso a micromolar".

Quercetin e ka ba tlatsetso ea bohlokoa ho batho ba bangata

Ho nahanela mefuta e mengata ea melemo ea quercetin, e ka 'na ea e-ba tlatsetso e molemo ho batho ba bangata, ebang ke mathata a maholo kapa a nako e telele, e ka ba le phello e itseng. Hona hape ke tlatsetso eo ke khothaletsang hore u e boloke ka har'a khabinete ea meriana. E ka ba molemo ha u ikutloa hore u mothating oa "ho imeloa" ke bothata ba bophelo bo botle (ebang ke sefuba se tloaelehileng kapa feberu).

Haeba u tloaetse ho tšoaroa ke sefuba le ntaramane, u ka nahana ho nka quercetin likhoeli tse 'maloa pele ho nako ea serame le feberu ho matlafatsa sesole sa hau sa' mele. Ha nako e ntse e ea, ho bonahala ho le molemo haholo ho bakuli ba nang le metabolic syndrome, empa ke bothoto haholo ho itšetleha feela ka li-supplement tse itseng le ho hlōleha ho rarolla mathata a mantlha a kang lijo le boikoetliso ka nako e le 'ngoe.