Har'a lipampiri tsa morao-rao mabapi le antioxidant ena e matla ke tlhahlobo e phatlalalitsoeng ho Phytotherapy Research ka Hlakubele 2019, e ileng ea hlahloba lintlha tse 9 mabapi le litlamorao tsa quercetin ho metabolism syndrome Teko e laoloang ka mokhoa o sa reroang.

Lefu la metabolism le bolela letoto la mathata a bophelo bo botle a eketsang kotsi ea lefu la tsoekere la mofuta oa 2, lefu la pelo le stroke, ho kenyeletsoa khatello e phahameng ea mali, tsoekere e phahameng ea mali, maemo a phahameng a triglyceride le ho bokellana ha mafura thekeng.

Leha lithuto tse felletseng li fumane hore quercetin ha e na phello ho tsoekere maling a itimang, ho hanyetsa insulin kapa maemo a hemoglobin A1c, tlhahlobo e 'ngoe ea lihlopha tse nyenyane e bontšitse hore quercetin e ile ea eketsoa lithutong tse ileng tsa nka bonyane 500 mg ka letsatsi bonyane libeke tse robeli. ”Tšoaetso ea mali ea itimang e fokotsehile haholo.

Quercetin e thusa ho laola tlhahiso ea liphatsa tsa lefutso

Ho ea ka phuputso e phatlalalitsoeng ka 2016, quercetin e ka boela ea kenya tšebetsong mocha oa mitochondrial oa apoptosis (lefu la sele le hlophisitsoeng la lisele tse senyehileng) ka ho sebelisana le DNA, ka hona e baka ho fokotseha ha hlahala.

Lithuto li fumane hore quercetin e ka baka chefo liseleng tsa leukemia, 'me phello e amana le tekanyo. Litlamorao tse fokolang tsa chefo liseleng le tsona li fumanoe liseleng tsa kankere ea matsoele. Ka kakaretso, quercetin e ka eketsa bophelo ba litoeba tsa kankere ka makhetlo a 5 ha e bapisoa le sehlopha sa taolo se sa phekoloang.

Bangoli ba amahanya litlamorao tsena le tšebelisano e tobileng pakeng tsa quercetin le DNA le ts'ebetso ea eona ea tsela ea mitochondrial ea apoptosis, 'me ba fana ka maikutlo a hore tšebeliso e ka bang teng ea quercetin e le setlhare se thusang bakeng sa kalafo ea mofetše e lokela ho hlahlojoa haholoanyane.

Phuputso ea morao tjena e phatlalalitsoeng koranteng ea Molecules e boetse e totobalitse litlamorao tsa epigenetic tsa quercetin le bokhoni ba eona ba ho:

Tšebelisano le liteishene tsa lipontšo tsa sele
Laola tlhahiso ea liphatsa tsa lefutso
Ama mosebetsi oa lintlha tsa phetolelo
E laola microribonucleic acid (microRNA)

Microribonucleic acid e kile ea nkoa e le DNA ea "lithōle". Liphuputso li fumane hore DNA ea "lithōle" ha e na thuso ho hang. Ha e le hantle ke molek'hule e nyenyane ea ribonucleic acid, e phethang karolo ea bohlokoa ho laoleng liphatsa tsa lefutso tse etsang liprotheine tsa batho.

Asiti e nyenyane ea microribonucleic e ka sebelisoa e le "phetoho" ea liphatsa tsena tsa lefutso. Ho ea ka tlhahiso ea asiti e nyane ea microribonucleic, jini e ka kenya khoutu efe kapa efe ea lihlahisoa tsa protheine tse fetang 200. Bokhoni ba Quercetin ba ho fetola li-microRNA bo ka boela ba hlalosa litlamorao tsa eona tsa chefo le hore na ke hobane'ng ha e bonahala e eketsa ho pholoha ha kankere (bonyane bakeng sa litoeba).

Quercetin ke motsoako o matla oa antiviral

Joalokaha ho boletsoe kaholimo, lipatlisiso tse entsoeng ho potoloha quercetin li shebane le bokhoni ba eona ba ho loantša vaerase, e leng se bakoang haholo-holo ke mekhoa e meraro ea ts'ebetso:

Thibela bokhoni ba likokoana-hloko ba ho tšoaetsa lisele
Thibela ho ikatisa ha lisele tse tšoaelitsoeng
Fokotsa ho hanyetsa ha lisele tse tšoaelitsoeng kalafo ea meriana e thibelang likokoana-hloko

Mohlala, phuputso e tšehelitsoeng ke Lefapha la Tšireletso la US e phatlalalitsoeng ka 2007 e fumane hore ka mor'a ho ba le khatello e matla ea 'mele, quercetin e ka fokotsa kotsi ea ho tšoaetsoa ke vaerase le ho ntlafatsa ts'ebetso ea hau ea kelello, ho seng joalo e ka senya ts'ebetso ea hau ea 'mele ea ho itšireletsa mafung, ea etsa hore u be kotsing ea mafu.

Phuputsong ena, bapalami ba libaesekele ba ile ba fumana 1000 mg ea quercetin ka letsatsi, e kopantsoeng le vithamine C (e eketsang maemo a quercetin maling) le niacin (e khothalletsang ho monngoa) ka libeke tse hlano tse latellanang. Liphetho li fumane hore ha ho bapisoa le ba sa phekoloang. Bakeng sa mopalami ofe kapa ofe oa libaesekele ea ileng a phekoloa, ba ileng ba nka quercetin ba ne ba e-na le monyetla o tlase haholo oa ho tšoaroa ke lefu la vaerase ka mor'a ho palama baesekele lihora tse tharo ka letsatsi ka matsatsi a mararo a latellanang. Batho ba 45% sehlopheng sa placebo ba ne ba kula, ha batho ba 5% feela sehlopheng sa kalafo ba ne ba kula.

Setsi sa US Defense Advanced Research Projects Agency (DARPA) se tšehelitse phuputso e 'ngoe, e ileng ea hatisoa ka 2008, 'me sa ithuta tšebeliso ea kokoana-hloko ea H1N1 e bakang mafu a mangata ho phephetsa liphoofolo tse phekoloang ka quercetin. Sephetho se ntse se tšoana, ho kula le ho shoa ha sehlopha sa kalafo ho ne ho le tlase haholo ho feta ha sehlopha sa placebo. Lithuto tse ling li boetse li tiisitse katleho ea quercetin khahlanong le mefuta e fapaneng ea livaerase, ho kenyeletsoa:

Phuputso e entsoeng ka 1985 e fumane hore quercetin e ka thibela tšoaetso le ho ikatisa ha kokoana-hloko ea herpes simplex ea mofuta oa 1, kokoana-hloko ea polio ea mofuta oa 1, kokoana-hloko ea parainfluenza ea mofuta oa 3, le kokoana-hloko ea phefumoloho ea syncytial.

Phuputso ea liphoofolo ka 2010 e fumane hore quercetin e ka thibela likokoana-hloko tsa ntaramane A le B. Ho boetse ho na le lintho tse peli tse kholo tse sibolotsoeng. Ea pele, likokoana-hloko tsena li ke ke tsa ba le khanyetso ho quercetin; ea bobeli, haeba li sebelisoa hammoho le meriana ea antiviral (amantadine kapa oseltamivir), liphello tsa tsona lia eketseha haholo - 'me nts'etsopele ea khanyetso ea thibeloa.

Phuputso ea liphoofolo ka 2004 e amohetse mofuta oa kokoana-hloko ea H3N2, e batlisisa phello ea quercetin ho ntaramane. Mongoli o bontšitse:

"Nakong ea tšoaetso ea kokoana-hloko ea ntaramane, khatello ea oxidative e hlaha. Hobane quercetin e ka khutlisa khatello ea li-antioxidants tse ngata, batho ba bang ba nahana hore e ka ba moriana o sebetsang o ka sireletsang matšoafo hore a se ke a lokolloa nakong ea tšoaetso ea kokoana-hloko ea ntaramane. Litlamorao tse kotsi tsa li-radical tse se nang oksijene."

Phuputso e 'ngoe ea 2016 e fumane hore quercetin e ka laola tlhahiso ea protheine 'me e na le phello e sireletsang vaerase ea ntaramane ea H1N1. Haholo-holo, taolo ea protheine ea ho tšoha ha mocheso, fibronectin 1 le protheine e thibelang e thusa ho fokotsa ho ikatisa ha vaerase.

Phuputso ea boraro e phatlalalitsoeng ka 2016 e fumane hore quercetin e ka thibela mefuta e fapaneng ea ntaramane, ho kenyeletsoa H1N1, H3N2, le H5N1. Mongoli oa tlaleho ea lipatlisiso o lumela hore, "Phuputso ena e bontša hore quercetin e bontša ts'ebetso ea thibelo mohatong oa pele oa tšoaetso ea ntaramane, e fanang ka moralo oa kalafo o ka khonehang nakong e tlang ka nts'etsopele ea meriana ea tlhaho e sebetsang hantle, e bolokehileng le e theko e tlaase ho phekola le ho thibela tšoaetso ea [kokoana-hloko ea ntaramane A]."

Ka 2014, bafuputsi ba ile ba supa hore quercetin "e bonahala e tšepisa kalafong ea sefuba se tloaelehileng se bakoang ke li-rhinovirus" 'me ba eketsa ka ho re, "Liphuputso li tiisitse hore quercetin e ka fokotsa ho kenngoa le ho ikatisa ha livaerase ka har'a vitro. 'Mele o ka fokotsa mojaro oa vaerase, pneumonia le karabelo e matla ea moea."

Quercetin e ka boela ea fokotsa tšenyo ea oxidative, ka hona ea fokotsa kotsi ea tšoaetso ea baktheria ea bobeli, e leng sesosa se seholo sa mafu a amanang le ntaramane. Habohlokoa le ho feta, quercetin e eketsa biosynthesis ea mitochondrial mesifa ea masapo, e leng se bontšang hore karolo ea phello ea eona ea antiviral e bakoa ke lets'oao le matla la antiviral la mitochondrial.

Phuputso ea liphoofolo ka 2016 e fumane hore quercetin e ka thibela kokoana-hloko ea dengue le tšoaetso ea kokoana-hloko ea hepatitis ho litoeba. Lithuto tse ling le tsona li tiisitse hore quercetin e na le bokhoni ba ho thibela tšoaetso ea hepatitis B le C.

Haufinyane tjena, phuputso e phatlalalitsoeng koranteng ea Microbial Pathogenesis ka Hlakubele 2020 e fumane hore quercetin e ka fana ka tšireletso e felletseng khahlanong le tšoaetso ea Streptococcus pneumoniae ka har'a vitro le ka har'a vivo. Chefo (PLY) e lokolloang ke pneumococcus ho thibela ho qhoma ha tšoaetso ea Streptococcus pneumoniae. Tlalehong ea "Microbial Pathogenesis", mongoli o bontšitse:

"Liphetho li bontša hore quercetin e fokotsa haholo ts'ebetso ea hemolytic le cytotoxicity e bakoang ke PLY ka ho thibela ho thehoa ha li-oligomers."
Ho phaella moo, kalafo ea quercetin e ka boela ea fokotsa tšenyo ea lisele e tsamaisoang ke PLY, ea eketsa sekhahla sa ho pholoha ha litoeba tse tšoaelitsoeng ke litekanyetso tse bolaeang tsa Streptococcus pneumoniae, ea fokotsa tšenyo ea matšoafo, le ho thibela li-cytokine (IL-1β le TNF) ho lokolloeng ha mokelikeli oa bronchoalveolar lavage. -α).
Ha re nahana ka bohlokoa ba liketsahalo tsena ho pathogenesis ea Streptococcus pneumoniae e sa foleng, liphetho tsa rona li bontša hore quercetin e ka ba moemeli e mocha oa lithethefatsi bakeng sa kalafo ea tšoaetso ea pneumococcal ea kliniki.
Quercetin e loantša ho ruruha le ho matlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung

Ntle le ts'ebetso ea antiviral, quercetin e ka boela ea ntlafatsa sesole sa 'mele le ho loantša ho ruruha. Phuputso ea 2016 e phatlalalitsoeng koranteng ea Nutrients e bontšitse hore mekhoa ea ts'ebetso e kenyelletsa (empa ha e felle feela ho) thibelo ea:

• Tumor necrosis factor alpha (TNF-α) e bakoang ke lipopolysaccharide (LPS) ho macrophages. TNF-α ke cytokine e amehang ho ruruha ha tsamaiso ea 'mele. E ntšoa ke macrophages e sebetsang. Macrophages ke lisele tsa 'mele tse ka metsang lintho tse tsoang linaheng tse ling, likokoana-hloko le likarolo tse ling tse kotsi kapa tse senyehileng.
• Maemo a TNF-α le interleukin (Il)-1α mRNA a bakoang ke lipopolysaccharide liseleng tsa glial, e leng se ka lebisang ho "ho fokotseha ha apoptosis ea lisele tsa neuronal"
• Thibela tlhahiso ea li-enzyme tse bakang ho ruruha
• Thibela khalsiamo ho phallela liseleng, ka hona e thibela:
◦ Ho lokolloa ha li-cytokine tse bakang ho ruruha
◦ Lisele tsa mast tsa mala li lokolla histamine le serotonin 

Ho ea ka sengoloa sena, quercetin e ka boela ea tsitsisa lisele tsa mast, ea ba le ts'ebetso ea cytoprotective tsamaisong ea mala, 'me "e na le phello e tobileng ea taolo litšobotsing tsa mantlha tsa ts'ebetso ea lisele tsa' mele", e le hore e ka "fokotsa kapa ea thibela mefuta e fapaneng ea litsela le mesebetsi ea ho ruruha," ea thibela palo e kholo ea lipheo tsa limolek'hule tse fapaneng tsa mahloriso a micromolar".

Quercetin e ka ba tlatsetso e molemo ho batho ba bangata

Ha re nahana ka melemo e mengata ea quercetin, e ka ba tlatsetso e molemo ho batho ba bangata, ebang ke mathata a matla kapa a nako e telele, e ka ba le phello e itseng. Ena ke tlatsetso eo ke e khothaletsang hore u e boloke ka har'a khabinete ea meriana. E ka ba molemo ha u ikutloa u le mothating oa ho "imetsoe" ke bothata ba bophelo bo botle (ebang ke sefuba kapa ntaramane).

Haeba o na le tšekamelo ea ho tšoaroa ke sefuba le ntaramane, o ka 'na oa nahana ho nka quercetin likhoeli tse 'maloa pele ho nako ea sefuba le ntaramane ho matlafatsa sesole sa hau sa' mele. Qetellong, ho bonahala ho le molemo haholo ho bakuli ba nang le metabolic syndrome, empa ke booatla haholo ho itšetleha feela ka li-supplement tse itseng le ho hloleha ho rarolla mathata a mantlha a kang lijo le boikoetliso ka nako e le 'ngoe.