Asiti ea Shikimic ke eng?

Asiti ea Shikimic (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) ke motsoako oa tlhaho oa tlhaho o leng karolo ea bohlokoa ea biosynthesis ea lignin, li-amino acid tse nkhang hamonate (phenylalanine, tyrosine le tryptophan), le boholo ba li-alkaloid tsa limela le tsa likokoana-hloko.

Asiti ea Shikimic e sebelisoa hangata e le thepa ea ho qala bakeng sa tlhahiso ea indasteri ea moriana o thibelang likokoana-hloko oa oseltamivir (moriana oa kokoana-hloko ea H5N1 o sebelisetsoang ho phekola le ho thibela mefuta eohle e tsebahalang ea kokoana-hloko ea ntaramane). Ho tlalehiloe hore tlhahiso ea (-)-zeylenone e thehiloeng ho Shikimic Acid e sebelisoa haholo e le moemeli oa chemotherapy ea mofetše. Lintlha lia fumaneha mabapi le tlhahiso ea monopalmitoyloxy Shikimic Acid, e nang le ts'ebetso ea anticoagulant 'me e khona ho fokotsa ho kopana ha mali ha e fanoa ka methapo. Sehlopha sa bafuputsi sa Chaena se hlahisitse derivative ea Shikimic Acid, triacetyl Shikimic Acid, e bonts'ang ts'ebetso ea anticoagulant le antithrombotic.

Ho phaella moo, di-derivative tsa Shikimic Acid di bontshitse thahasello e kgolo temong kaha tse ngata tsa tsona di sebediswa e le dibolaya-dikokwana-hloko le di-antimicrobial agent hobane di ka thibela tsela ya Shikimic Acid dimeleng le dibaktheria ntle le ho ama diphoofolo tse anyesang hampe.

Ka hona, Shikimic Acid e ka sebediswa e le seathomo bakeng sa tlhahiso ya manyolo ka hara saense ya motheo le ditshebediso tsa bongaka k'hemistring ya manyolo le meriana, haholoholo bakeng sa ho lokisa dithethefatsi tse fapaneng.

E le thepa ea bohlokoa ea lik'hemik'hale tsa meriana, asiti ea shikimic e ka sebelisoa kalafong ea mafu a mangata:

1. E loantšang baktheria le hlahala

Ka 1987, litsebi tsa Majapane li fumane hore analoge ea glyoxalase I inhibitor e entsoeng ke methyl anthranilate e na le phello e totobetseng ea thibelo holim'a mohala oa sele ea Hela le Escheri ascites carcinoma, e ka lelefatsa nako ea ho phela ha litoeba tse entetsoeng ka sele ea leukemia L1210, 'me chefo e batla e le tlase, phello ea eona ea thibelo e amana haholo le karabelo ea sulfur hydride. 1988, litsebi tsa Machaena li na le Ka 1988, litsebi tsa Machaena li entse derivative ea shikimic acid 'me tsa paka hore motsoako ona o na le phello ea ho thibela lisele tsa leukemia L1210 ka har'a vitro.

2. Thibelo ea ho thothomela ha mali

Tšusumetso ea asiti ea shikimic le metsoako ea eona tsamaisong ea pelo le methapo ea mali e bontšoa karolong ea ho loantša thrombosis le thibelo ea ho bokellana ha liplatelete. Lipatlisiso li bontša hore: asiti ea shikimic e na le phello e matla ea thibelo sekhahla sa ho bokellana ha liplatelete tsa mohlala oa adenosine diphosphate-induced middle cerebral artery embolism; ente ea shikimic acid ka methapo le ka hare ho mesifa e ka etsa hore nako ea ho hoama mali ea litoeba e lelefale.

3. Ho senyeha ha boko ho thibelang ho ruruha ha boko

Asiti ea Shikimic le metsoako ea eona e na le phello ea ho ntlafatsa ischemia ea boko, haholo-holo ho fokotseng bophahamo ba infarction ea boko ka mor'a ischemia ea boko e shebaneng le likhoto, ho fokotsa lintlha tsa ts'ebetso ea methapo ea kutlo, ho fokotsa tekanyo ea edema ea boko, ho eketsa phallo ea mali ea boko sebakeng sa ischemic le matšoao a mang. Lithuto tse ling li bontšitse hore metsoako ea eona e ka fokotsa tekanyo ea ho bokellana ha erythrocyte le ho thibela ho bokellana ha liplatelete ka mor'a ischemia ea boko, ka hona ho nolofatsa microcirculation ea boko.